Supplement Interaction Safety Guidelines

Your Safety is Our Priority

At Puraiva Nutrition, we believe informed customers make the best wellness decisions. Our Supplement Interaction Safety Guidelines provide essential information about safely combining our science-backed supplements with medications and other products. Whether you're new to supplements or stacking multiple products, these guidelines help you maximize benefits while minimizing risks.

What You'll Find Here:

  1. Medication interaction warnings for all Puraiva products
  2. Safe combination recommendations for product stacking
  3. Optimal timing guidelines for maximum effectiveness
  4. Clear guidance on when to consult your healthcare provider
  5. Emergency warning signs to watch for

These guidelines are for educational purposes and don't replace professional medical advice. Always consult your healthcare provider before starting new supplements, especially if you take medications or have health conditions.

⚕️Medication Interactions by Product

AshwaVital Ashwagandha

Can I take AshwaVital™ with blood pressure medication?

Use caution when combining AshwaVital™ with blood pressure medications. Ashwagandha may naturally lower blood pressure, which could enhance the effects of BP medications and potentially cause blood pressure to drop too low. Monitor your blood pressure closely and consult your healthcare provider before combining these. Signs to watch for include dizziness, lightheadedness, or fainting.

Is AshwaVital™ safe with diabetes medications?

AshwaVital™ may enhance blood sugar-lowering effects of diabetes medications. While this isn't necessarily dangerous, it requires careful monitoring to prevent hypoglycemia (low blood sugar). Check your blood sugar more frequently when starting AshwaVital™ and work with your healthcare provider to adjust medication dosages if needed.

Will AshwaVital™ interfere with my thyroid medication?

Yes, AshwaVital™ can affect thyroid function and may increase thyroid hormone levels. This is particularly concerning if you have hyperthyroidism or take thyroid medications. Have your thyroid levels monitored more frequently and consult your endocrinologist before starting AshwaVital™.

Can I take AshwaVital™ with immunosuppressive drugs?

Avoid combining AshwaVital™ with immunosuppressive medications. Ashwagandha stimulates immune system activity, which could counteract medications designed to suppress immune function (used after organ transplants or for autoimmune conditions). This combination could reduce the effectiveness of your prescribed medications.

Magnesium Glycinate

How does magnesium interact with antibiotics?

Magnesium can significantly reduce the absorption of certain antibiotics, particularly tetracyclines and quinolones (like ciprofloxacin). Take magnesium at least 2-3 hours before or 4-6 hours after antibiotic doses to avoid this interaction. Never take them simultaneously as this could make your antibiotic treatment less effective.

Can I take magnesium with heart medications?

Magnesium can interact with several heart medications, including digoxin and calcium channel blockers. While magnesium is generally heart-healthy, it can affect how these medications work and may influence heart rhythm. Always consult your cardiologist before adding magnesium supplements to your routine.

 Is magnesium safe with diuretics?

This depends on the type of diuretic. Some diuretics cause magnesium loss, making supplementation beneficial, while others (potassium-sparing diuretics) combined with kidney problems could cause magnesium buildup. Your healthcare provider needs to monitor your electrolyte levels when combining these.

Turmeric + BioPerine®

Can I take turmeric if I'm on blood thinners?

Exercise extreme caution. Turmeric has natural anticoagulant properties that can increase bleeding risk when combined with blood thinners like warfarin, Coumadin, or even aspirin. The BioPerine® in our formula increases absorption, potentially amplifying this effect. Stop turmeric 2 weeks before any surgery and have your INR monitored more frequently if your doctor approves use.

Will turmeric affect my diabetes medication?

Turmeric may enhance the blood sugar-lowering effects of diabetes medications, potentially causing hypoglycemia. Monitor your blood sugar more closely when starting turmeric supplements and be prepared to adjust medication dosages with your healthcare provider's guidance.

Is turmeric safe during chemotherapy?

Consult your oncologist before taking turmeric during chemotherapy. The BioPerine® in our formula increases the absorption of various compounds, which could potentially affect how chemotherapy drugs work in your system. Some cancer treatments may be enhanced or hindered by turmeric's anti-inflammatory properties.

Digestin Digestive Enzymes

Are digestive enzymes safe with acid-blocking medications?

Generally yes, but timing matters. Acid-blocking medications (PPIs, H2 blockers) reduce stomach acid, while digestive enzymes work best in acidic environments. Take Digestin with meals and your acid-blocking medication as prescribed by your doctor, typically 30-60 minutes before eating.

Can I take Digestin with diabetes medications?

Digestin is generally safe with diabetes medications, but improved digestion may affect how quickly carbohydrates are absorbed, potentially impacting blood sugar timing. Monitor your blood sugar patterns when starting Digestin, especially if you take rapid-acting insulin with meals.

Organic Sea Moss + BioPerine®

 Can I take sea moss with thyroid medication?

Use caution. Sea moss is naturally high in iodine, which can affect thyroid function. If you take thyroid medications (especially for hypothyroidism), the additional iodine could alter your thyroid hormone levels. Have your thyroid function tested more frequently and consult your endocrinologist.

Is sea moss safe with blood thinners?

Sea moss may have mild blood-thinning properties, and the BioPerine® could enhance absorption of various compounds. While generally milder than turmeric's effects, still consult your healthcare provider if you're on prescription blood thinners.

👍 Safe Product Combinations

Recommended Combinations

Which Puraiva products work best together?

A: Our most synergistic combinations include:

  • Digestin + Magnesium Glycinate: Supports digestive health and muscle relaxation
  • Sea Moss + K2+D3: Provides comprehensive mineral and vitamin support
  • Sugar Stop + Tru Beets: Supports healthy blood sugar and circulation
  • AshwaVital™ + Magnesium Glycinate: Excellent for stress management and sleep quality

Can I take Digestin with Magnesium Glycinate?

Absolutely! This is one of our recommended combinations. Take Digestin with meals to support digestion, and Magnesium Glycinate in the evening to promote relaxation and better sleep. They work through different pathways and complement each other well.

Is it safe to combine Sea Moss with K2+D3?

Yes, this is an excellent combination! Sea Moss provides essential minerals while K2+D3 supports bone health and calcium utilization. Take both with a meal containing healthy fats for optimal absorption of the fat-soluble vitamins.

Can I stack Sugar Stop with Tru Beets?

This is a great combination for metabolic support! Take Sugar Stop 30 minutes before meals to help manage blood sugar response, and Tru Beets can be taken with meals or pre-workout for circulation support. They work through different mechanisms and complement each other.

Combinations Requiring Caution

How much magnesium is too much when combining products?

Stay under 400mg of elemental magnesium daily from supplements (food sources don't count toward this limit). Our Magnesium Glycinate contains 200mg per serving. Check other Puraiva products for additional magnesium content and adjust accordingly. Excess magnesium can cause digestive upset and diarrhea.

Can I take multiple adaptogenic supplements together?

Start slowly when combining adaptogens like AshwaVital™ with other adaptogenic herbs. Begin with half doses of each for the first week to assess your body's response. Some people are more sensitive to adaptogens, and combining them can initially cause fatigue or digestive changes as your body adjusts.

What's the maximum number of Puraiva products I can take daily?

Most customers safely use 3-4 Puraiva products daily when properly spaced and dosed. The key is avoiding ingredient overlap (especially magnesium) and timing them appropriately. Our personalization quiz can help determine the optimal combination for your specific needs and goals.

⏰Optimal Timing Guidelines

Morning Supplements

Which supplements should I take in the morning?

Best morning supplements include:

  • K2+D3 Capsules: Support bone health and immune function throughout the day
  • Sea Moss: Provides sustained energy and mineral support
  • Tru Neuro: Supports cognitive function for the day ahead
  • Sugar Stop: If taking before breakfast to manage morning blood sugar

Should I take K2+D3 with food?

Yes! K2 and D3 are fat-soluble vitamins that require dietary fat for proper absorption. Take with breakfast or any meal containing healthy fats like avocado, nuts, olive oil, or eggs. Taking on an empty stomach significantly reduces absorption.

When is the best time for Sea Moss?

Morning is ideal for Sea Moss as it provides sustained energy throughout the day. Take with breakfast to maximize mineral absorption and avoid any potential energizing effects interfering with sleep. The iodine content also supports healthy thyroid function, which is most active during daytime hours.

Evening Supplements

Which supplements are best taken at night?

Evening supplements include:

  • Magnesium Glycinate: Promotes muscle relaxation and better sleep quality
  • AshwaVital™: If it makes you drowsy (some people find it energizing)
  • Digestin: Only if eating a late dinner

Can AshwaVital™ Ashwaghanda help with sleep?

AshwaVital™ can support better sleep by reducing cortisol levels and promoting relaxation, but individual responses vary. Some people find it energizing and prefer morning dosing, while others find it calming for evening use. Start with morning dosing and switch to evening if you find it promotes relaxation.

Why should I take Magnesium Glycinate in the evening?

Magnesium promotes muscle relaxation, nervous system calm, and can improve sleep quality. The glycinate form is particularly gentle and less likely to cause digestive upset. Taking it 30-60 minutes before bed helps prepare your body for restful sleep and supports overnight muscle recovery.

With or Without Food

Which supplements need to be taken with meals?

Take with food:

  • K2+D3: Requires fat for absorption
  • Turmeric + BioPerine®: Reduces stomach irritation and improves absorption
  • Digestin: Take with meals to support digestion
  • Sea Moss: Better absorbed with food and less likely to cause nausea

 Should digestive enzymes be taken with food?

Yes! Digestin should be taken at the beginning of meals or within 30 minutes of eating. The enzymes need food to work on - taking them on an empty stomach provides no benefit and may cause stomach irritation.

Can I take Sugar Stop on an empty stomach?

Yes, Sugar Stop (White Kidney Bean extract) is most effective when taken 30 minutes before meals on an empty stomach. This allows the active compounds to be ready to work when you consume carbohydrates. If you experience stomach upset, try taking with a small amount of food.

⚠️High-Risk Situations

Medical Conditions

When should I consult my doctor before taking supplements?

Consult your healthcare provider before starting supplements if you:

  • Take any prescription medications
  • Have chronic health conditions (diabetes, heart disease, kidney/liver problems)
  • Are pregnant, breastfeeding, or trying to conceive
  • Have a history of supplement allergies or sensitivities
  • Are scheduled for surgery within 2 weeks
  • Have an autoimmune condition or take immunosuppressive drugs

Are Puraiva supplements safe during pregnancy?

Many supplements require special consideration during pregnancy. While some ingredients like magnesium may be beneficial, others like ashwagandha are not recommended during pregnancy. Always consult your obstetrician before starting any new supplements while pregnant or breastfeeding.

Can I take supplements with kidney disease?

Kidney disease significantly affects how your body processes supplements, particularly minerals like magnesium. Your kidneys may not be able to properly eliminate excess nutrients, leading to dangerous buildup. Work closely with your nephrologist to determine which supplements are safe for your specific kidney function level.

What about liver conditions and supplements?

Your liver processes many supplement compounds, and liver disease can affect this process. Some supplements may be hepatotoxic (liver-damaging) in certain individuals or interact with liver medications. Consult your hepatologist before starting any new supplements if you have liver conditions.

Surgical Considerations

Should I stop supplements before surgery?

Yes, stop these supplements at least 2 weeks before scheduled surgery:

  • Turmeric + BioPerine®: Increases bleeding risk
  • AshwaVital™: May affect anesthesia and blood pressure
  • Sea Moss: High iodine content may affect thyroid function during surgery Continue magnesium and basic vitamins unless your surgeon advises otherwise.

Which supplements affect blood clotting?

Supplements that may affect blood clotting include:

  • Turmeric: Has anticoagulant properties
  • Sea Moss: Mild blood-thinning effects
  • High-dose Magnesium: Can affect platelet function Always inform your surgeon about all supplements you're taking.

How long before surgery should I stop taking supplements?

Stop blood-affecting supplements 2 weeks before surgery, but continue essential nutrients like basic vitamins unless advised otherwise. Create a list of all supplements for your surgical team, and ask specifically about each one during your pre-operative consultation.

⛔Warning Signs & Emergency Situations

Common Side Effects

What are normal side effects when starting supplements?

Common, typically harmless adjustment symptoms include:

  • Mild digestive changes (first 3-7 days)
  • Slight energy level fluctuations
  • Changes in bowel movements (especially with magnesium or digestive enzymes)
  • Mild headaches (usually from detox effects) These should resolve within 1-2 weeks as your body adjusts.

How long do adjustment symptoms last?

Most adjustment symptoms resolve within 1-2 weeks. Digestive changes typically improve within 3-7 days, while energy level stabilization may take up to 2 weeks. If symptoms persist beyond 2 weeks or worsen, discontinue use and consult your healthcare provider.

When should mild symptoms concern me?

Contact your healthcare provider if you experience:

  • Symptoms lasting longer than 2 weeks
  • Symptoms that worsen instead of improve
  • Any symptom that interferes with daily activities
  • Digestive upset that prevents eating or drinking
  • Sleep disturbances lasting more than a few days

Emergency Warning Signs

What symptoms require immediate medical attention?

Seek immediate medical care for:

  • Severe allergic reactions: Difficulty breathing, swelling of face/throat, severe rash
  • Unusual bleeding: Nosebleeds, easy bruising, blood in urine/stool
  • Severe digestive symptoms: Persistent vomiting, severe abdominal pain, bloody stools
  • Cardiovascular symptoms: Chest pain, irregular heartbeat, severe dizziness
  • Neurological symptoms: Severe headache, confusion, vision changes

Signs of dangerous supplement interactions?

Warning signs of dangerous interactions include:

  • Blood sugar dropping too low (shakiness, confusion, sweating)
  • Blood pressure dropping dangerously (fainting, severe dizziness)
  • Excessive bleeding from minor cuts
  • Severe mood changes or agitation
  • Rapid or irregular heartbeat
  • Difficulty breathing or chest tightness

When to call 911 vs. contact my doctor?

Call 911 for: Difficulty breathing, chest pain, loss of consciousness, severe allergic reactions, uncontrolled bleeding
Contact your doctor for: Persistent mild symptoms, questions about interactions, gradual worsening of known conditions, non-emergency side effects that concern you.

🩵Special Populations

Pregnancy & Breastfeeding

Which Puraiva supplements are safe during pregnancy?

Generally considered safer options include:

  • Magnesium Glycinate: Often recommended during pregnancy
  • Digestin: Usually safe but consult your OB Avoid during pregnancy: AshwaVital™, high-dose Sea Moss (iodine concerns) Always consult your obstetrician before starting any supplements during pregnancy.

Can I continue supplements while breastfeeding?

Some supplements transfer to breast milk and may affect your baby. Magnesium and basic digestive enzymes are typically safe, but ashwagandha and high-iodine supplements like sea moss should be used cautiously. Discuss each supplement individually with your pediatrician and OB.

Do I need different dosages when pregnant?

Yes, pregnancy often requires adjusted dosages. Your body's needs change significantly during pregnancy, and what's safe for a non-pregnant adult may be too much or too little during pregnancy. Your obstetrician can help determine appropriate dosages based on your specific needs, trimester, and any pregnancy complications.

Seniors (65+)

Are there special considerations for older adults?

Yes, seniors have unique considerations:

  • Slower metabolism: May need lower doses or longer time between doses
  • Multiple medications: Higher risk of drug-supplement interactions
  • Kidney/liver function: May be reduced, affecting supplement processing
  • Absorption issues: May need higher doses of certain nutrients or specific forms
  • Chronic conditions: More likely to have conditions requiring medical supervision

How do medications affect supplement absorption in seniors?

Common senior medications can significantly impact supplement absorption:

  • Acid-reducing medications (common in seniors): Reduce absorption of minerals and B vitamins
  • Blood thinners: Interact with many supplements
  • Diabetes medications: May interact with blood sugar-affecting supplements
  • Heart medications: Can be affected by magnesium and other minerals Always review supplements with your pharmacist and all your doctors.

Should dosages be adjusted for age?

Often yes. Seniors typically benefit from:

  • Starting with lower doses: Begin with 50% of standard adult dose
  • Gradual increases: Increase slowly to assess tolerance
  • More frequent monitoring: Regular check-ins with healthcare providers
  • Timing adjustments: May need different timing due to medication schedules Work with a geriatrician or pharmacist familiar with supplement-medication interactions.

Athletes & Active Individuals

Are there interaction concerns with sports supplements?

Yes, several potential interactions exist:

  • Pre-workout supplements + AshwaVital™: May cause overstimulation or blood pressure changes
  • Protein powders + Digestin: Generally safe and may enhance protein absorption
  • Creatine + Magnesium: Safe combination, may support muscle function
  • Fat burners + Turmeric: Monitor for excessive stimulation Always check ingredient lists for overlap, especially with stimulants.

Can I take pre-workout with Puraiva products?

Use caution with these combinations:

  • Pre-workout + AshwaVital™: Start with reduced doses of both to assess tolerance
  • Pre-workout + Tru Beets: Generally safe, may enhance nitric oxide effects
  • Pre-workout + Magnesium: Take magnesium post-workout or evening to avoid interference Avoid taking stimulant-containing pre-workouts with any supplement that affects blood pressure.

Timing supplements around training sessions?

ptimal timing for athletes:
Pre-workout (30-60 minutes before):

  • Tru Beets (for nitric oxide support)
  • Sugar Stop (if eating pre-workout carbs)

Post-workout:

  • Magnesium Glycinate (for recovery)
  • Digestin (if eating post-workout meal)

Non-training days:

  • AshwaVital™ (for recovery and stress management)
  • Sea Moss (for mineral replenishment)